XyloCor Therapeutics is a biopharmaceutical company focused on the development of novel gene therapy for unmet needs in advanced coronary artery disease. In the United States, coronary artery disease is a leading cause of death and disability. Our lead product candidate, XC001, is in clinical development for patients with refractory angina for which there are no treatment options. XyloCor also has a secondary product, XC002, in discovery stage, for patients with cardiac tissue damage from heart attacks.
Improve the lives of people who struggle with daily activities due to cardiovascular disease through our commitment to advancing the science of gene therapy.
XyloCor founders Dr. Ronald Crystal and Dr. Todd Rosengart started their collaboration in the 1990s at Weill Cornell Medical College where they combined their expertise in gene therapy and cardiac surgery to develop potential treatments for patients with advanced coronary artery disease. Their work continues to be referenced by the scientific community and is the foundation for the creation of XyloCor and its clinical programs. XyloCor holds exclusive license from Weill Cornell Medical College for the gene therapy being developed by the company.
Al Gianchetti has more than 25 years of drug development and commercialization experience, including over 10 years in the cardiovascular/metabolic therapeutic area. He has held executive level roles at GSK and additional leadership roles with small biotech and specialty pharma companies including Vanda Pharmaceutics. Mr. Gianchetti has extensive experience in both commercial strategy/operations and R&D including seven Phase III programs, over 10 Phase I/II programs and several product launches.
Elizabeth Tarka, MD is a cardiologist and served as an Assistant Professor of Medicine in the Cardiovascular Division at the University of Pennsylvania where she had numerous major teaching and clinical responsibilities. She then transitioned to the Pharmaceutical Industry and worked for GlaxoSmithKline and Janssen Pharmaceuticals where she held various positions in the clinical development of cardiovascular medications and was responsible for the design, implementation, and medical oversight for large multinational trials. Most recently, Dr. Tarka was the CMO at Idera Pharmaceuticals with a strategic focus in immuno‑oncology.
Howard Dittrich, MD, is a cardiologist and Adjunct Professor of Medicine and Chair of the Board of Directors of the François M. Abboud Cardiovascular Research Center at the University of Iowa Carver College of Medicine. He is the former CMO at Cirius Therapeutics and other biotech companies including NovaCardia, Sequel and Laguna. Dr. Dittrich has extensive experience in regenerative medicine for CV disease.
Dawn Byrnes has 23 years of experience working in the clinical research industry, including involvement across all roles of project/portfolio management. Her background spans all phases of research, I‑IV, in a variety of indications including Cardiovascular, Hematology/Oncology and multiple rare diseases. Ms. Byrnes held several leadership roles including Global Operations Lead and Region Head for the Americas in her career at PPD.
Mark Peterson holds valued experience in clinical trial management, working on multiple Phase I/II and Phase III studies in various therapeutic areas. He served as the project administration lead on his studies while at PPD, in addition to holding other clinical trial site management positions.
Jennifer Augusti has over a decade of experience in financial valuation, budgeting and operations for biopharmaceutical companies. Her previous roles include progressive experience with investment and commercial banks and consulting work for numerous clinical stage biotech companies. She began her career at JPMorgan in investment banking performing financial analysis, modeling and due diligence.
With more than 25 years of experience in the biopharmaceutical industry, Alex Gaidamaka has a wealth of biologics R&D expertise including preclinical, process & analytical development, GMP manufacturing and validations. He also has significant regulatory experience across multiple technology platforms from his tenures with Sanofi Group, AmpliPhi Biosciences, Personalized Onco Therapeutics Inc. and other companies. Dr. Gaidamaka has a PhD in immunology and microbiology and is a Doctor of Veterinary Medicine.
Rémi Gloeckler, PhD, has more than 25 years of experience in quality and manufacturing leadership in gene and cellular therapy. He was Transgene’s Vice President of pharmaceutical and industrial operations and then formed Pharmincell in September 2011 where he has consulted for leading gene therapy companies both in Europe and North America.
Fouad Azzam, PhD, an experienced venture capital leader, joined LSP in 2007 and became a General Partner of the firm later that same year. His prime focus and responsibility within LSP is to invest in unlisted securities... LEARN MORE >> and manage the firm’s North American operations. Prior to joining LSP, Dr. Azzam was the Managing Director of Eastman Ventures where he built-up its Healthcare and Advanced Materials practice. As Managing Director, he was responsible for numerous early- and late-stage investments across the US and Europe. Prior to his role at Eastman Ventures, Dr. Azzam held senior leadership positions in innovation and corporate development at Eastman Chemical as well as operating and technology roles at Occidental Chemical and BFGoodrich. Dr. Azzam is currently a Director at BioClin Therapeutics, Cardiac Dimensions, Endotronix, Illuminoss Medical, and Simplify Medical. << CLOSE
Mr. Batchelder’s most recent operational role was as co‑founder and CEO of Civitas Therapeutics (sold to Acorda). Prior to Civitas he served as CEO of BIND Therapeutics (sold to Pfizer) and Acceleron Pharma (NASDAQ:XLRN). LEARN MORE >> He started his biotechnology career at Millennium Pharmaceutical serving in roles of increasing responsibility including SVP of Operations.
Mr. Batchelder also currently serves as Executive Chairs of Synchronicity Pharma and Kantum Bio. He also serves on the boards of The Possible Project and the Michael J. Fox Foundation. He previously served as the Chair of the Board for MassBio. He received a BS in Chemical Engineering from Lehigh University. << CLOSE
Alan Colowick, MD, currently serves on the Board of Directors of Personalis, Harpoon Therapeutics, and InCarda. He was recently Chairman of the Board of Principia (acquired by Sanofi) and VelosBio (acquired by Merck). LEARN MORE >>
Dr. Colowick is a former partner at Sofinnova Ventures. Before joining Sofinnova, he held executive management and board of director positions at numerous companies in the biotechnology sector. Most recently, he was Executive Vice President at Celgene Corporation, and prior to that held positions of President for Celgene’s Europe, Mid‑East, and Africa regions as well as Senior Vice President of Global Medical Affairs. Previously, Dr. Colowick was the Chief Executive Officer at Gloucester Pharmaceuticals, Inc. until its acquisition by Celgene in 2010. Before becoming CEO at Gloucester Pharmaceuticals, he was President, Oncology for Geron Corporation and was Chief Medical Office of Threshold Pharmaceuticals. Prior to that, Dr. Colowick held numerous positions of increasing responsibility at Amgen Inc culminating with his role as VP, Medical Affairs Europe.
Dr. Colowick received an MD from Stanford University and an MPH from Harvard University. Additionally, he completed specialty training in Hematology-Oncology at the Dana Farber Cancer Institute and Brigham and Women’s Hospital. He has a BS in Molecular Biology from the University of Colorado. << CLOSE
Ronald Crystal, MD, is Bruce Webster Professor and Chairman, Department of Genetic Medicine, Weill Cornell Medical College and Director of the Belfer Gene Therapy Core Facility. He has been a leader in gene therapy... LEARN MORE >> for more than 20 years and developed the FDA-approved therapy for alpha-1 antitrypsin deficiency. Dr. Crystal is also the first to use a recombinant virus as a vehicle for in vivo gene therapy. << CLOSE
Al Gianchetti has more than 25 years of drug development and commercialization experience, including over 10 years in the cardiovascular/metabolic therapeutic area. LEARN MORE >>He has held executive level roles at GSK and additional leadership roles with small biotech and specialty pharma companies including Vanda Pharmaceutics. Mr. Gianchetti has extensive experience in both commercial strategy/operations and R&D including seven Phase III programs, over 10 Phase I/II programs and several product launches. << CLOSE
With over 20 years of investment banking, corporate development, and licensing and investment experience, Dr. Daniel Hetu has been involved with life sciences companies at all stages of development in North America and overseas. LEARN MORE >> With demonstrated success managing complex initiatives, projects and transactions, he is recognized for his strategic thinking and problem‑solving skills.
Dr. Hetu’s investment activities are focused on building companies in the therapeutics and medical device sectors that develop products and technologies with a direct and significant impact on patient care. He manages Lumira Ventures’ Montreal office.
An experienced senior executive with leading expertise in financing and corporate business development, he spent 10 years at Shire Pharmaceuticals and at Biochem Pharma prior to its acquisition by Shire. As vice president, business development (North America) and vice president, corporate development, respectively, he led several financing, licensing and M&A transactions in the therapeutics, vaccine, and diagnostics sectors. At Biochem, as well as serving on the company’s portfolio committee and the steering committee of strategic research collaborations, Dr. Hetu served on the boards of investee companies. Prior to joining Biochem Pharma, he was an investment banker at a major Canadian Investment Bank where he was involved in M&A and financing transactions across various industrial sectors. << CLOSE
Aidan King is Managing Partner and co‑founder of Fountain Healthcare Partners. Aidan is a pharmacist by training who started his career at Elan in pharmaceutical strategic marketing before moving to their corporate venture capital group. LEARN MORE >>He then joined BIO‑IB, a boutique investment bank, before founding Fountain Healthcare Partners. Aidan currently sits on the board of Syndesi Therapeutics. He is a CFA charter holder and received his MBA from University College Dublin. << CLOSE
John de Koning, PhD, is a partner at LSP (Life Sciences Partners), one of Europe’s leading investors in the healthcare sector. Prior to joining LSP in 2006, Dr. Koning was the Managing Director of Semaia Pharmaceuticals (acquired by Hybrigenics). LEARN MORE >>Previously, he was a senior researcher within several prestigious medical research labs. Dr. Koning currently serves on the boards of Merus (NASDAQ: MRUS), eTheRNA, GTX medical and Aelin Therapeutics. He also served on the boards of several other companies, such as argenx (NASDAQ: ARGX), BMEYE (acquired by Edwards Lifesciences) and Prosensa (acquired by BioMarin). << CLOSE
Perry Nisen, MD, is a physician scientist with extensive experience in drug discovery and development. He is on the Board of Directors of Teva Pharmaceuticals, Executive Chairman and interim CEO of Quanta. LEARN MORE >>Prior to joining Sofinnova Investments as Executive Partner, he was CEO of the Sanford Burnham Prebys Medical Discovery Institute (SBP). As CEO, Dr. Nisen was responsible for all aspects of the organization including strategy, operations and performance. Prior to SBP, he held multiple senior leadership positions during his tenure at GlaxoSmithKline (GSK) including SVP of Science and Innovation, interim Chief Medical Officer, and Oncology Therapy Area Head. When he was the Oncology Therapy Area Head, he was accountable for the Oncology portfolio from target to market. Responsibilities at GSK included all aspects of drug discovery, clinical development, risk/benefit and operations. Before GSK, Dr. Nisen was the Divisional Vice President, Cancer Research at Abbott Laboratories. Prior to industry, he was the Lowe Foundation Professor at the University of Texas Southwestern Medical Center. Dr. Nisen holds a BS from Stanford University, and MD/PhD from the Albert Einstein College of Medicine. << CLOSE
Lizzie Ngo, PhD, is a Senior Associate at Longwood Fund, where she is involved in creating and supporting portfolio companies. She was previously an Associate at Flagship Pioneering and was a co‑founder of several Flagship ventures. LEARN MORE >>Dr. Ngo received her PhD from MIT in Biological Engineering under the supervision of Professors Leona Samson and Bevin Engelward. As part of her PhD research, she developed high‑throughput assays for quantitation of DNA damage and repair and applied them to assess individuals’ cancer susceptibility. Dr. Ngo’s graduate work resulted in publications in several peer‑reviewed journals, a pending patent, and multiple awards from the Environmental Mutagenesis & Genomics Society and the MIT Center of Environmental Health Sciences. Prior to her doctorate, she received her B.A. in Genetics with a minor in Mathematics from Rutgers University, where she graduated summa cum laude and was named the top graduating student in her class. << CLOSE
Todd Rosengart, MD, is Professor and DeBakey-Bard Chairman, Department of Surgery, Baylor Medical College; Professor of Heart and Vascular Disease at the Texas Heart Institute. LEARN MORE >>He has been a leading researcher in cardiac angiogenesis and regeneration for more than 30 years and together with Ron Crystal, M.D. was the first to administer the adenovirus vector for cardiac gene transfer in the U.S. Dr. Rosengart is also co‑founder of Vitals.com << CLOSE
Nikhil Thatte joined Lumira Ventures as a Principal in March 2019. He is responsible for investment sourcing and due diligence and is focused on next generation modalities including cell and gene therapy. LEARN MORE >>Prior to Lumira Ventures, Mr. Thatte worked as a Director with DRI Capital, a pioneer in healthcare royalty monetization, and as a Consultant with ZS Associates, a global pharmaceutical consulting firm. He holds a Bachelor’s Degree in Chemical Engineering from McGill University. << CLOSE